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Year : 2020  |  Volume : 26  |  Issue : 4  |  Page : 199-204

Oral submucous fibrosis and risk of eustachian tube dysfunction: A meta-analysis

1 Department of Periodontics and Implantology, VSPM Dental College and Research Centre, Nagpur, Maharashtra, India
2 Department of ENT, NKP Salve Institute of Medical Sciences, Nagpur, Maharashtra, India
3 Department of PSM, Government Medical College, Nagpur, Maharashtra, India

Correspondence Address:
Dr. Surekha R Rathod
Department of Periodontics and Implantology, VSPM Dental College and Research Centre, Digdoh Hills, Hingna Road, Nagpur, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/indianjotol.INDIANJOTOL_191_20

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Introduction: Oral submucous fibrosis (OSF) is a chronic disease, affecting the oral cavity and sometimes the pharynx. It is always associated with juxtaepithelial inflammatory reaction followed by fibroelastic changes of the lamina propria, with epithelial atrophy leading to the oral mucosa and causing trismus and inability to eat. It may also involve the pharyngeal orifice of the eustachian tube (ET). Objective: The aim of this systematic review and meta-analysis was to synthesize the available evidence to determine the effect of OSF on ET function. Materials and Methods: Title and the protocol for the systematic review and meta-analysis were registered in Prospero. Individual with OSF, observational case–control study, human trials, and the article published in English language were included in the study. There were no limits on the number of patients were taken in cases or control groups. Results: The overall pooled odd ratio (OR) of hearing impairment for with OSF compared without OSF was 10.65 with 95% confidence interval (CI) =3.17–35.74. A positive association between OSF and prevalence of ET dysfunction was observed between the study characteristic. A strong and significant association between hearing impairment and OSF was observed (OR = 10.56, 95% CI = 3.17–35.75, P = 0.001). Conclusion: Results of our meta-analysis demonstrates increased risk of hearing impairment in patients with OSMF.

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