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ORIGINAL ARTICLE
Year : 2019  |  Volume : 25  |  Issue : 3  |  Page : 155-161

Intranasal hyaluronic acid improves the audiological outcomes of children with otitis media with effusion


1 Department of Translational Medicine, Otolaryngology, University of Rome “Tor Vergata,” ,Rome, Italy
2 Department of Translational Medicine, Otolaryngology;Departement of System Medicine, Neuroscience Unit, University of Rome “Tor Vergata,” Rome, Italy
3 Department of Environmental and Occupational Medicine, National Institute for Insurance Against Accidents at Work (INAIL), Rome, Italy
4 Department of Applied Clinical Sciences and Biotechnology, L'Aquila University, Coppito, Italy

Correspondence Address:
Dr. Federica Martino
Viale Giulio Agricola, 6 00174 Rome
Italy
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/indianjotol.INDIANJOTOL_107_18

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Background/Aim: We evaluated the efficacy and compliance of a therapeutic approach based on intranasally-administered hyaluronic acid (HA) in the treatment of chronic otitis media with effusion (OME) in pediatric patients. Materials and Methods: Forty-four pediatric patients were enrolled and randomized into two groups: the first one (Group A) received a treatment based on HA and Group B was treated with saline solution only. Both therapies were intranasally administered by compressed-air nebulizer and Rinowash, a nebulizer designed to treat the upper airway structures. Patients were evaluated by medical history, otoscopy, pure-tone audiometry, and impedentiometry at 0 (T0), 4 (T1), 12 (T2), and 16 (T3) weeks. Results: The analysis of tympanometric and audiometric data, such as the evaluation of otoscopic improvements, showed significant differences between the two groups. After just 1 month of therapy, (T1) tympanometric evaluation showed greater improvements in Group A. Data on the audiometric threshold improvements, measured at different stages of the treatment, showed a greater improvement of the mean/median value of the auditory thresholds in patients treated with HA than in patients of Group B. Conclusion: The absence of side effects and the results observed make this therapeutic approach a potential valid alternative in the difficult long-term management of OME.


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