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Year : 2017  |  Volume : 23  |  Issue : 4  |  Page : 237-240

GSTP1 levels in cisplatin-induced rat cochlea after alpha lipoic acid and oxytocin treatment

1 Department of Otorhinolaryngology, Kartal Dr. Lutfi Kirdar Kartal Training and Research Hospital, Istanbul, Turkey
2 Department of Otorhinolaryngology, Etimesgut State Hospital, Ankara, Turkey
3 Department of Biology, Faculty of Arts and Sciences, Kirikkale University, Kirikkale, Turkey
4 Department of Pathology, Kartal Dr. Lutfi Kirdar Kartal Training and Research Hospital, Istanbul, Turkey

Correspondence Address:
Dr. Sedat Aydin
Istasyon Caddesi Merdivenli Sokak N: 5 D: 6, Kartal, İstanbul
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/indianjotol.INDIANJOTOL_137_16

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Introduction: Cisplatin is a well-known chemotherapeutic agent used in many cancer treatments. Several antioxidant agents are used for diminishing the toxic side effects of the cisplatin therapy. Alpha-lipoic acid (α-LA) and oxytocin (OT) are antioxidant agents that can be used in toxicity. Our aim is to investigate the effect of these antioxidants in cisplatin-induced ototoxicity in tissue level. Materials and Methods: Forty Wistar albino rats divided into five groups as control, cisplatin, cisplatin + intraperitoneal (IP) OT, cisplatin + intratympanic (IT) OT, and cisplatin + IT α-LA. The drug administration is applied for 4 days, and at the end of the procedure, the cochleas are harvested. After tissue preparation, GSTP1 levels are investigated and the intensity of the reaction is scored as negative (−), weak (1+), moderate (2+), or strong (3+). Results: Group 4 has a moderate staining which can be interpreted as high immunoreaction. When we compare with Group 1, this staining difference is statistically significant (P < 0.02). When we observe the Group 3, we cannot detect any difference with Group 1 in immunoreactivity. Conclusion: α-LA and OT are antioxidants effective against cisplatin ototoxicity. The expression of GSTP1 isozyme is increased in antioxidant-treated groups. Increased levels of these isozymes proved the increased healing response in tissue levels. Antioxidant agents can be used for adverse effects during cisplatin treatment. IT route is effective as IP systemic route.

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